Neurodegenerative diseases and flavonoids

Author: Mariam Shengelia
Keywords: Flavonoids, neurodegenerative diseases, neuroprotection, cognitive functions
Annotation:

Neurodegenerative diseases (ND) result from the gradual and progressive degeneration of the structure and function of the central nervous system or the peripheral nervous system. During the past several years, there has been enormous progress in the understanding of the causative factors that initiate neuronal damage in various neurodegenerative diseases, including Alzheimer disease, Parkinson disease, multiple sclerosis, and Huntington disease. Because most neurodegenerative diseases are late-onset and remain asymptomatic for most of the phases, the therapies initiated in advanced stages of the disease have limited value to patients. Such therapies may restore neuronal function by reducing or even eliminating the primary stressor. Flavonoids are secondary metabolites of plant origin widely investigated at present and represent one of the most important and diversified among natural products phenolic groups. Flavonids reduce the risk of neurodegenerative diseases. In addition to their antioxidant properties, these polyphenolic compounds exhibit neuroprotective properties by their interaction with cellular signaling pathways and can prevent the loss of nervous cells.

Lecture files:

ნეიროდეგენერაციული დაავადებები და ფლავონოიდები [ka]