Some Aspects of Formation of Organic Acids in Biosystems

Author: Ramaz Gakhokidze
Keywords: Carbohydrates, organic acids, intramolecular rearrangement
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Organic acids play the leading part in metabolism – reduction of carbonic acids during photosynthesis and oxidation of carbohydrates during the breathing process takes place with participation of organic acids. It is accepted, that formation and utilization of organic acids during breathing process is realized by means of two chemical ways – glycolysis and pentosophosphatic. We supposed the alternative course of formation of organic acids in living organisms by intermolecular rearrangement of carbohydrates. On the basis of intramolecular rearrangement of carbohydrates a suggestion is made by us with respect to the formation of organic acids may occur via the intramolecular rearrangement of glucose, involving the intermediates: 2-deoxygluconic acid, 3,4-dihydroxyadipic acid and 3,4-diketoadipic acid, which undergoes a benzilic acid type of rearrangement, giving citric acid. For establishment of analogous process in vivo, the experiments were carried out on unicellular organisms, namely on suspension on intact Saccharomyces cerevisiae cells.