Separation of enantiomers of chiral sulfoxides with chloro-methyl-substitued tris- phenylcarbamate of cellulose as chiral selectors in high-performance liquid chromatography

Author: natia shashviashvili
Co-authors: Mari-luiza Konjaria
Keywords: ქირალური სელექტორი, ქირალური სულფოქსიდი, მოძრავი ფაზა
Annotation:

We’ve carried out screening of newly synthesized chiral sulfoxides on their chiral recognition ability with tris-phenylcarbamate derivatives of cellulose as chiral selectors in high-performance liquid chromatography. By systematic variation of the chemistry and structure of chiral selectors and selectands those structural features must be prevailed which are most critical for selector-selectand binding and chiral recognition ability. Current experiment includes the study of only columns with chloro-methyl substitued-phenylcarbamates and some interesting results have been obtained. Our experiment was held by high-performance liquid chromatography. We have tested chiral sulfoxides: 2-(benzylsulfinyl)benzamide and its bromo- and methyl- substituted derivatives chiral selectors used in the experiment were Cellulose-2 and Cellulose-4. with methanol, ethanol, isopropanol and the mixture of n- Hexane and isopropanol as mobile phases:.Results of the experiment have shown that chiral recognition ability is dramatically affected by the fine structural modification of the structure of a chiral selector or selectand. Cellulose-4 gave us the best results.